Ray is young, charming, successful and the owner of a prosperous architect company. However, he has recently gone through a very painful divorce. His friends try to cheer him up by showing him the positive sides of being single but for Ray marriage and stability is just too important. But when he meets Lena his gloom is quickly forgotten. She is beautiful, sensual, mysterious and he is drawn to her like a moth to a candle. They marry quickly, have their first child and Ray lives in a total bliss. But then strange incidents occur which shed some light on Lena's background. Ray slowly realizes that he hardly knows anything about her at all. Who has he really married?

Ray is a man obsessed with his own mortality. When Ray's best friend dies of a heart attack, Ray is convinced that all of his aches and pains are an indication of his own imminent death. His life turns into a slapstick farce of health-crazed anxiety and hypochondria, until he finally learns that all he has to fear is fear itself.

On the day after his fortieth birthday, the family man and computer analyst George Grieves goes to the Mt. Abaddon Hospital for a routine procedure of colonoscopy with Dr. Sharazi. Along his birthday party, his friends and family tell many cases of medical errors, and George is worried about. After the surgery, George finds that his surgery had complications because of a homonymous patient, and he had received a thoracoscopic sympathectomy instead. While interned, George discloses bizarre and dark secrets about the East Wing of the hospital while his wife and family have to take a decision about his fate.